References

≠ In a clinical trial to evaluate on-eye performance of Total30® for Astigmatism lenses where n=69; Alcon data on file,2021

√Compared to competitive reusable contact lenses: Acuvue Oasys for Astigmatism, Biofinity Toric and Bausch + Lomb Ultra for Astigmatism^

* Dk/t = 156 @ -3.00D. Compared with TruEye, Clariti 1 day and MyDay

¥ Other factors may impact eye health

** Image is for illustrative purposes and not an exact representation.

^ Based on DAILIES® AquaComfort PLUS® sphere contact lenses

β Based on >80% agreeing or strongly agreeing with the statement "The lenses were so comfortable I didn't feel anything" in a study (n=66) using AOSept solution for nightly cleaning, disinfecting, and storing; Dailies Total 1® Spherical contact lenses Alcon data on file, 2021

§ With 2 lenses or less per eye, based on DAILIES AquaComfort PLUS Multifocal and AIR OPTIX AQUA MULTIFOCAL contact lenses

µ - There is no demonstrated clinical benefit to a 334% reduction in visible light at wavelengths below 450 nm. UV absorbing contact lenses are NOT substitutes for protective UV absorbing eyewear, such as UV absorbing goggles or sunglasses because they do not completely cover the eye and surrounding area. The patient should continue to use UV absorbing eyewear as directed

µ. Pitt, et al. Loading and Release of a Phospholipid From Contact Lenses. Optom Vis Sci. 88 (4).2011

⒫ Based on clinical studies of the PRECISION BALANCE 8|4™ Lens Design with AIR OPTIX® for Astigmatism contact lenses; n=163

Ω In a clinical study at 5 sites in the US; n=39

λ Based on Focus® DAILIES® Toric contact lenses.

† Based on investigator assessment of lens rotation, at one week; using investigational lenses with -.75, -1.5 cylinder powers (D).

Ⱡ Based on clinical studies with AIR OPTIX AQUA MULTIFOCAL contact lenses

π Based on clinical studies with AIR OPTIX AQUA contact lenses, compared to Biofinity^, PureVision^, ACUVUE^ OASYS^, ACUVUE^ ADVANCE^ and Avaira^ contact lenses.

⌂ Compared to AIR OPTIX AQUA contact lenses

∆ With two lenses or fewer per eye

∞ AIR OPTIX NIGHT & DAY AQUA lenses are approved for daily wear and for up to 30 nights' continuous wear. Not everyone can wear lenses for a full 30 nights. An Eye care practitioner must be consulted.

***The commercially available competitor contact lenses included in these studies were balafilcon A (PureVision; Bausch & Lomb) comfilcon A (Biofinity; CooperVision), enfilcon A (Avaira; CooperVision), galyfilcon A (ACUVUE ADVANCE; Johnson & Johnson Vision Care), and senofilcon A (ACUVUE OASYS; Johnson & Johnson Vision Care)

φ The wearing and replacement schedule should be determined by an eye care professional based on the individual’s needs and physiological conditions. Not everyone can wear lenses during sleep or reach the maximum wear time of 30 continuous nights


  1. Maissa C, et al. Evaluation of the Lubricity of TOTAL1® contact lenses after wear. Opt Vis Sci Annual meeting 2014
  2. Kern J, Rappon J, Bauman E, Vaughn B. Assessment of the relationship between contact lens coefficient of friction and subject lens comfort. ARVO 2013 Annual Meeting Abstract
  3. Based on the ratio of lens oxygen transmissibilities, among daily disposable lenses; Alcon data on file 2010
  4. Nichols JJ, Willcox MDP, Bron AJ, et al. The TFOS International Workshop on Contact Lens Discomfort: Executive Summary. Invest Ophthalmol Vis Sci. 2013;54:TFOS7–TFOS13. DOI:10.1167/iovs.13-13212
  5. Tighe BJ. A decade of silicone hydrogel development: surface properties, mechanical properties and ocular compatibility. Eye & Contact Lens. 2013;39:4-12
  6. Based on the ratio of lens oxygen transmissibilities. Alcon data on file 2009
  7. Senchyna M, et al. Characterization of a Multi-Purpose Lens Solution Designed for Silicone Hydrogel Materials. Poster presented at: ARVO; May 2010; Fort Lauderdale, FL
  8. In vitro study measuring mean cholesterol deposition with 6 different lens brands before and after cleaning with 6 different commercially available lens care solutions. Lens materials tested were lotrafilcon A, lotrafilcon B, lotrafilcon B toric, comfilcon A, senofilcon A, balafilcon A. Alcon data on file, 2012
  9. Borazjani RN, McAnally C, et al. Antibacterial, Antifungal and Antiamoebal Properties of a Novel Multi-Purpose Solution. Investigative Ophthalmology & Visual Science April 2010. Vol 51, 3414
  10. Pérez-Gómez I, Giles T. European survey of contact lens wearers and eye care professionals on satisfaction with a new water gradient daily disposable contact lens. ClinicalOptometry. 2014;6:17-23
  11. Alcon data on file, 2013
  12. Pitt WG, Jack DR, Zhao Y, Nelson JL, Pruitt JD. Loading and release of a phospholipid from contact lenses. OptomVis Sci. 2011;88(4):502-506
  13. Perry SS, Huo S, Rudy A, Angelini TE, Sawyer WG. Tribology Laboratory. Hydrogel modulus measurements; Alcon data on file, 2013
  14. Bauman E, Lemp J, Kern J. Material Effect on Multifocal Contact Lens Fitting of Lenses of the Same Optical Design with the Same Fitting Guide. BCLA poster abstract, June 2017
  15. Alcon data on file, 2020
  16. Cummings S, Giedd B, Pearson C. Clinical performance of a new daily disposable spherical contact lens. Optom Vis Sci. 2019;96:Eabstract 195375
  17. Alcon Data on file 2019
  18. In a randomized, subject-masked, multi-site clinical study with over 150 patients; significance demonstrated at 0.05 level; Alcon data on file 2005
  19. Wolffsohn, J, Hunt, O, Chowdhury, A. Objective clinical performance of ‘comfort enhanced’ daily disposable soft contact lenses. Contact Lens & Anterior Eye. 2010;33:88-92
  20. Pruitt , Triple-action moisturisers for increased comfort in daily disposable lenses, Optician 2007; 16.11: 27-28
  21. Bringing comfort to the masses: a novel evaluation of comfort agent solution properties. White CJ, Thomas CR, Byrne ME. Cont Lens Anterior Eye. 2014 Apr;37(2):81-91
  22. Alcon data on file, 2011
  23. In randomized, double-masked clinical study with 104 patients; significance demonstrated at the 0.05 level; Alcon data on file, 2011
  24. In a subject masked clinical trial (n=93); Alcon data on file, 2010
  25. Winterton L, Lally J, Sentell K, Chapoy L. The elution of (vinyl alcohol) from a contact lens: The realisation of a time release moisturising agent/artificial tear. J Biomed Mater Res B Appl Biomater, 2007;80B:424-43
  26. Eiden SB, Davis R, Bergenske P. Prospective study of Iotrafilcon B lenses comparing 2 versus 4 weeks of wear for objective and subjective measures of health, comfort and vision. Eye & Contact Lens. 2013;39(4):290-294
  27. In vitro wetting analysis: out-of-pack and wetting substantivity. Alcon data on file, 2014
  28. In vitro study over 16 hours to measure wetting substantivity; Alcon data on file, 2015
  29. Nash W, Gabriel M, Mowrey-McKee M. A comparison of various silicone hydrogel lenses; lipid and protein deposition as a result of daily wear. Optom Vis Sci. 2010;87:E-abstract 105110
  30. Nash WL, Gabriel MM. Ex vivo analysis of cholesterol deposition for commercially available silicone hydrogel contact lenses using a uorometric enzymatic assay. Eye Contact Lens. 2014;40(5):277-282
  31. Keir N, Jones L. Wettability and silicone hydrogel lenses: a review. Eye Contact Lens. 2013;39:100-8
  32. Carney FP, Nash WL, Sentell KB. The adsorption of major tear film lipids in vitro to various silicone hydrogels over time. Invest Ophthalmol Vis Sci. 2008;49:120-4
  33. Lemp J, Kern J. On-eye performance of lotrafilcon B lenses packaged with a substantive wetting agent. Poster presented at Optometry’s Meeting, the Annual Meeting of the American Optometric Association; June 21-25, 2017; Washington, D.C.
  34. In a prospective, crossover, single-masked clinical trial. Evaluation of lotrafilcon B multifocal contact lenses versus PureVision^ Multifocal contact lenses in emerging presbyopes. Alcon data on file, 2008.
  35. Woods J, Woods C, Fonn D. Visual performance of a multifocal contact lens versus monovision in established presbyopes. Optom Vis Sci. 2015;92(2):175-182
  36. Lemp J, Kern J. A comparison of real time and recall comfort assessments. Optom Vis Sci. 2016;93:E-abstract 165256
  37. Nash W, Gabriel M, Mowrey-McKee M . A comparison of various silicone hydrogel lenses; lipid and protein deposition as a result of daily wear. Optom Vis Sci. 2010;87: E-abstract 105110
  38. One month clinical comparison of two lotrafilcon B spherical lenses with different packaging solutions, Alcon data on file, 2017
  39. Internal memo from the designers of the Alcon multifocal PRECISION PROFILE(tm) contact lens design; Alcon data on file, 2016
  40. Lemp J, Zhao X, Perry S. Retention of packing solution comfort agents. Poster presented at 2017 American Academy of Optometry Annual Meeting; 11-14 October, 2017; Chicago, IL
  41. Mann A, Tighe B. Contact lens interactions with the tear film. Exp Eye Res. 2013;117:88-98. 5. Rohit A, Willcox M, Stapleton F. Tear lipid layer and contact lens comfort: a review. Eye Contact Lens. 2013;39(3):247-253
  42. Robert C. Tucker, In vitro and on eye wettability of lotrafilcon B lenses packaged with a substantive wetting agent, ARVO 2017
  43. CE Technical File for Air Optix (Lotrafilcon B) Family Soft Contact Lens.In a randomised, subject masked, multi-site clinical with over 150 patients; significance demonstrated at the 0.05 level; Alcon data on file, 2005
  44. Versus any available soft contact lens based on the ratio of lens oxygen transmissibilities; Alcon data on file, 2009, 2010
  45. Dk/t 175 @-3.00D
  46. Alcon data on file, 2012
  47. Sindt CW & Foulkes GN. Efficacy of an artificial tear emulsion in patients with dry eye associated
  48. Nash WL, Gabriel MM. Ex vivo analysis of cholesterol deposition for commercially available silicone hydrogel contact lenses using a uorometric enzymatic assay. Eye Contact Lens. 2014;40(5):277-282
  49. Wolffsohn J, Hunt O, Chowdhury A. Objective clinical performance of ‘comfort-enhanced’ daily disposable soft contact lenses. Cont Lens Anterior Eye. 2010;33(2):88-92
  50. Performance of lotrafilcon B Silicone Hydrogel Contact Lenses in Experienced Low-Dk/t Daily Lens Wearers, Dillehay S, Miller M, Eye & Contact Lens 2007, Vol 33(6)
  51. Dk/[email protected]. Other factors may impact eye health
  52. Michauda L, Forcier P. Comparing two different daily disposable lenses for improving discomfort related to contact lens wear. Contact lens and anterior eye. Vol 854
  53. Ham BM, Cole RB, Jacob JT. Identification and comparison of the polar phospholipids in normal and dry eye rabbit tears by MALDI-TOF mass spectrometry. Invest Ophthalmol VisSci. 2006;47(8):3330-3338
  54. Alcon data on file, 201
  55. Paugh J, Brennan N Efron N. Ocular response to hydrogen peroxide. Am J of Opt & Physical Optics. 1988;(65):2,91-98
  56. Alcon Data on file, 2015
  57. Lally J, Ketelson H, Borazjani R, et al. r and comfort with today’s CLs. Optician 4/1/2011, Vol 241 Issue 6296, 42-46
  58. Davis J, Ketelson HA, Shows A, Meadows DL. A lens care solution designed for wetting silicone hydrogel materials. Poster presented at ARVO; May 2010; Fort Lauderdale, FL
  59. Campbell R, Kame G, et al. Clinical benefits of a new multi-purpose disinfecting solution in silicone hydrogel and soft contact lens users. Eye & Contact Lens 2012:38(2);93-101
  60. Third party industry reports 2005-2009 and Alcon data on file, 2012
  61. Rosenthal R, Sutton S, Schlech B. Review of standards for evaluating the effectiveness of contact lens disinfectants. PDA J Pharm Sci And Tech. 2002;56(1):37-50
  62. Santos L. Lens material and formulation of multipurpose solutions affects contact lens disinfection. Contact Lens & Anterior Eye 34 (2011); 179-182
  63. Davis J, Ketelson H.A, Shows A, Meadows D.L. A lens care solution designed for wetting silicone hydrogel materials. Poster presented at: ARVO; May 2010; Fort Lauderdale, FL.
  64. Rosenthal RA, et al. Antimicrobial spectrum of a new contact lens disinfectant. Poster presented during the annual meeting of the American Academy of Optomery, San Diego, Calif. December 2005
  65. Stiegemeier MJ et al. Clinical performance of ‘no rub’ multi-purpose solutions. Contact Lens & Anterior Eye 2004;27:65-74
  66. Meadows D. et al. Clinical Ex Vivo Wettability of Traditional and Silicone Hydrogel Soft Contact Lenses. Poster presented at BCLA; May 2006; Birmingham, UK.
  67. Epstein A. Understanding and Managing Risk in Contact Lens Wear. Contact Lens Spectrum,March 2009
  68. Corbin GS. A multicenter investigation of OPTI-FREE Replenish multi-purpose disinfecting solution impact on soft contact lens patient comfort. Clinical Ophthalmology December 2010:4; 47–57
  69. Guillon, M., 2013. Are silicone hydrogel contact lenses more comfortable than hydrogel contact lenses?. Eye & contact lens, 39(1), pp.86-92
  70. Rangarajan, R. and Ketelson, H., 2019. Preclinical evaluation of a new hydroxypropyl-guar phospholipid nanoemulsion-based artificial tear formulation in models of corneal epithelium. Journal of Ocular Pharmacology and Therapeutics, 35(1), pp.32-37Systane® COMPLETE PIL
  71. Alcon data on file
  72. Benelli U. Systane Lubricant eye drops in the management of ocular dryness. Clinical Ophthalmology, Dove press 2011
  73. Systane® BALANCE Packaging/PIL
  74. Systane® ULTRA Packaging/PIL
  75. Cohen S, Martin A, Sall K. Evaluation of clinical outcomes in patients with dry eye disease using lubricant eye drops containing polyethylene glycol or carboxymethycellulose. Clin Ophthalmol. 2014;8:157-167
  76. Systane® GEL DROPS Packaging/PIL
  77. Belda-Salmerón L, Ferrer-Blasco T, Albarrán-Diego C, Madrid-Costa D, Montés-Micó R. Diurnal variations in visual performance for disposable contact lenses. Optom Vis Sci. 2013;90(7):682-690
  78. Thekveli S, Qui Y, Kapoor Y, et al. Structure-property relationship of delefilcon A lenses. Cont Lens Anterior Eye. 2012;35(Supp1):e14
  79. Angelini T, Nixon R, Dunn A, et al. Viscoelasticity and mesh-size at the surface of hydrogels characterized with microrheology. ARVO 2013. E-abstract 114872
  80. In a clinical study wherein patients (n=66) AOSEP® solution for nightly cleaning, disinfecting, and storing; Alcon data on file, 2021

  81. Shi X, Cantu-Crouch D, Sharma V, et al. Surface characterization of a silicone hydrogel contact lens having bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer layer in hydrated state. Colloids Surf B: Biointerfaces. March 2021;199:111539

  82. Surface property analysis of lehfilcon A lenses out of pack and after 30 days of wea

  83. In vitro laboratory measurement of lens surface modulus; Alcon data on file, 202

  84. In vitro laboratory analysis of lens oxygen permeability, water content, and surface imaging; Alcon data on file 2021

  85. Shi X, Cantu-Crouch D, Sharma V, et al. Surface characterization of a silicone hydrogel contact lens having bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer layer in hydrated state. Colloids Surf B: Biointerfaces. March 2021;199:111539.

  86. In vitro evaluation of bacterial adherence in commercial lenses: Alcon data on file, 2020

  87. In vitro evaluation of bacterial biofilm in commercial lenses: Alcon data on file, 2020

  88. In vitro evaluation of lipid deposition for lehfilcon A and commercial lenses using 3D confocal imaging; Alcon data on file, 2021

  89. Ishihara K, Fukazawa K, Sharma V, Liang S, et al. Antifouling silicone hydrogel contact lenses with a bioinspired 2 methacryloyloxyethyl phosphorylcholine polymer surface. ACS Omega. 2021;6:7058-7067

  90. Laboratory assessment of ultraviolet and visible light transmission properties of lehfilcon A contact lenses using spectrophotometer; Alcon data on file, 2020

  91. ISO 18369-2:2017 Ophthalmic optics — Contact lenses Part 2: Tolerances ANSI Z80.20-2016 ophthalmic contact lens UV transmittance

  92. Laboratory measurement of oxygen permeability by polarographic method; https://coopervision.com/practitioner/our-products/biofinity-family/biofinity-biofinity-xr. Accessed March 10, 2021

  93. Angelini TE, Nixon RM, Dunn AC, et al. Viscoelasticity and mesh-size at the surface of hydrogels characterized with microrheology. Invest Ophthalmol Vis Sci. 2013;54:E-abstract 500
  94. Thekveli S, Qui Y, Kapoor Y, et al. Structure-property relationship of delefilcon A lenses. Cont Lens Anterior Eye. 2012;35(Supp 1):e14

  95. Pitt, et al. Loading and Release of a Phospholipid From Contact Lenses. Optom Vis Sci. 88(4).2011

    96. ⒫ Based on clinical studies of the PRECISION BALANCE 8|4™ Lens Design with AIR OPTIX® for Astigmatism contact lenses; n=163
    There is no demonstrated clinical benefit to a 33% reduction in visible light at wavelengths below 450 nm. UV absorbing contact lenses are NOT substitutes for protective UV absorbing eyewear, such as UV absorbing goggles or sunglasses because they do not completely cover the eye and surrounding area. The patient should continue to use UV absorbing eyewear as directed

  96. Doerte Luensmann et al, The Impact of Cosmetics on the Physical Dimension and Optical Performance of Silicone Hydrogel Contact Lenses, CCLR poster, 2012
  97. Janakiraman D P, Brobst A, Wang C. Performance Comparisons of a Silicone Hydrogel to Low DK Toric Soft Contact Lenses. Optom Vis Sci 2006;83:E-abstract 065263
  98. Guillon, M., 2013. Are silicone hydrogel contact lenses more comfortable than hydrogel contact lenses?. Eye & contact lens, 39(1), pp.86-92
  99. Alcon Data on file 2020, CLO870-C003 DAILIES TOTAL
  100. Alcon Data on file 2010
  101. Alcon data on file 07450, 2018
  102. Shi, X., Cantu-Crouch, D., Sharma, V., Pruitt, J., Yao, G., Fukazawa, K., Wu, J.Y. and Ishihara, K., 2021. Surface characterization of a silicone hydrogel contact lens having bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer layer in hydrated state. Colloids and Surfaces B: Biointerfaces, 199, p.111539
  103. A02491-REP-197506 v2.3 Surface Characteristics of lehfilcon A
  104. Alcon data on file. ISO 18369-2:2017 Ophthalmic optics — Contact lenses — Part 2: Tolerances / Table 4 Tolerance Limits, 2017
  105. Codling, C.E., Maillard, J.Y. and Russell, A.D., 2003. Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine. Journal of Antimicrobial Chemotherapy, 51(5), pp.1153-1158
  106. Alcon Data on file. US-OFM-1900004 Acanthamoeba white paper effectiveness of MPS against Acanthamoeba, 2019
  107. Surface property analysis of lehfilcon A lenses out of pack and after 30 days of wear; Alcon data on file, 2020
  108. Surface observations of lehfilcon A contact lens and human cornea using scanning transmissions electron microscopy; Alcon data on file, 2020
  109. Laboratory measurement of oxygen permeability by polarographic method; Alcon data on file, 2019
  110. Based on in vitro measurement of thickness profiles on unworn lenses; Alcon data on file, 2019
  111. Outermost Surface Softness Analysis of lehfilcon A Contact Lenses. Alcon data on file, 2021
  112. Surface Characteristics of lehfilcon A. Alcon data on file, 2021
  113. Alcon data on file, 2022

    114. AD INTERIM PRECISION7™

  114. In a 2-week prospective clinical study in the UKJ; n-181; CLEAR CARE Cleaning & Disinfecting Solution used for cleaning and disinfecting; Alcon date on file, 2023. (p=0.0353)
  115. Zheng Y, Dou J, Wang Y, et al. Sustained release of a polymeric wetting agent from a silicone-hydrogel contact lens material. ACS Omega. 2022;7(33):29223-29230. doi:10,1021/acsomega.2c03310.
  116. Alcon data on file, 2023.
  117. Phan CM, Chan VWY, Drolle E, et al. Evaluating the in vitro wettability and coefficient of friction of a novel and contemporary reusable silicone hydrogel contact lens materials using an in vitro blink model. Cont Lens Anterior Eye. 2024; Volume 47(2):1-11.

    118. AD INTERIM PRECISION7™ for Astigmatism

  118. In a 28-day prospective clinical study; n=92; Alcon data on file, 2023.
  119. In a 2-week prospective clinical study in the US; n=181; CLEAR CARE® Cleaning & Disinfecting Solution used for cleaning and disinfection; Alcon data on file, 2023. (p=0.0353)
  120. Zheng Y, Dou J, Wang Y, et al. Sustained release of a polymeric wetting agent from a silicone-hydrogel contact lens material. ACS Omega. 2022;7(33):29223-29230. doi:10,1021/acsomega.2c03310.
  121. Alcon data on file, 2023.
  122. Phan CM, Chan VWY, Drolle E, et al. Evaluating the in vitro wettability and coefficient of friction of a novel and contemporary reusable silicone hydrogel contact lens materials using an in vitro blink model. Cont Lens Anterior Eye. 2024; Volume 47(2):1-11

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